Triglycerides drop dramatically. LDL changes modestly. HDL trends up slightly. The honest numbers.

Triglycerides

Typical drop: 30–40% on tirzepatide, 25–35% on semaglutide, over 6 months. The biggest cholesterol-related benefit.

LDL ('bad cholesterol')

Modest drop, often 5–10%. Not the main lever — if your LDL is the primary concern, a statin remains first-line.

HDL ('good cholesterol')

Trends up slightly, especially with sustained weight loss and exercise.

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